ABNORMALLY ELEVATED USP37 EXPRESSION IN BREAST CANCER STEM CELLS REGULATES STEMNESS, EPITHELIAL-MESENCHYMAL TRANSITION AND CISPLATIN SENSITIVITY

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity

Abstract Background Recent studies have indicated that deubiquitinating enzymes (DUBs) are related to the stem-cell pathway network and chemo-resistance in cancer.Ubiquitin-specific peptidase 37 (USP37), a novel DUB, was identified to be a potential factor associated with Diecast Car tumor progression.However, the biological functions of USP37 in b

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Understanding spermatogenesis is a prerequisite for treatment

Abstract Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete.The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells an

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Differential gene expression in the liver of the African lungfish, Protopterus annectens, after 6 months of aestivation in air or 1 day of arousal from 6 months of aestivation.

The African lungfish, Protopterus annectens, can undergo aestivation during drought.Aestivation has three phases: induction, maintenance and arousal.The objective of this study was to examine the differential gene expression in the liver of P.annectens after 6 months (the maintenance phase) of aestivation as compared with the freshwater control, or

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